CLU 2-1 TOL · 54% YOK 1-2 KAW · 47% JEF 1-1 AVI · 42% V-V 1-0 TOK · 44% MAC 2-0 GAM · 62% AME 3-0 EYü · 71% PEC 1-1 ADO · 40% COM 2-0 VEN · 63% CER 1-2 ANT · 50% GET 0-1 SEV · 50% FAL 0-2 CEL · 62% DJU 2-0 DEG · 67% MAL 1-2 HAM · 52% ODE 1-1 SIL · 43% CLU 2-1 TOL · 54% YOK 1-2 KAW · 47% JEF 1-1 AVI · 42% V-V 1-0 TOK · 44% MAC 2-0 GAM · 62% AME 3-0 EYü · 71% PEC 1-1 ADO · 40% COM 2-0 VEN · 63% CER 1-2 ANT · 50% GET 0-1 SEV · 50% FAL 0-2 CEL · 62% DJU 2-0 DEG · 67% MAL 1-2 HAM · 52% ODE 1-1 SIL · 43%
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NFL · Regular Season · Week 3 Levi's Stadium, Santa Clara Finished

San Francisco 49ers
vs
Arizona Cardinals.

Quick answer

Who will win San Francisco 49ers vs Arizona Cardinals?

Final score: San Francisco 49ers 36–30 Arizona Cardinals. Before kickoff, 10 of 10 AI models pick San Francisco 49ers to win (100%); the consensus was right. The AI predicted score was 27–20.

Consensus of independent AI models on TuringStats, updated before kickoff. Not betting advice.

All 10 AIs agree. When the whole council agrees, it has been right 58% of the time (67 games).

10 AI models read this game. The plurality on the winner leans toward San Francisco 49ers (10 of 10 models). The mean predicted score (rounded from all models) is 27–20 at 64% mean confidence (Medium band) — see the strip and table below.

Who do you think will win?

Vote before kick-off and compare with AI

NFL standings Where San Francisco 49ers and Arizona Cardinals stand right now
— Consensus

Where the panel lands.

Vote share across models. Read this strip first, then the line-by-line table.

San Francisco 49ers win 100%

10 / 10 models

Arizona Cardinals win 0%

0 / 10 models

— Model breakdown

10 picks. Receipts attached.

Line-by-line comparison of each system’s call.

#
Model
Pick
Score
Conf.
Reasoning
01
GPT-6 Luna
San Francisco 49ers win
27–21
64%
San Francisco has won two of the past three meetings and gets the home-field advantage at Levi's Stadium. Arizona has shown upset potential, but the 49ers’ recent head-to-head scoring edge supports a competitive home win.
02
Claude Sonnet 5.5
San Francisco 49ers win
27–20
61%
49ers have dominated recent meetings and hold home-field edge at Levi's Stadium; Cardinals competitive but historically inconsistent on the road versus SF.
03
Gemini 3.8 Flash
San Francisco 49ers win
27–21
63%
San Francisco holds home advantage at Levi's Stadium, where their balanced offense should edge Arizona in a competitive division matchup.
04
Grok 4.7
San Francisco 49ers win
27–20
61%
Levi's Stadium home edge for San Francisco in Week 3; recent H2H mixed but 49ers often control NFC West at home. Cardinals stay competitive, one-possession gap.
05
DeepSeek V4 Pro
San Francisco 49ers win
27–20
58%
San Francisco has won two of the last three meetings, including 41-22 at Arizona in November, and holds a home-field edge at Levi's Stadium. Arizona's offense can keep it close, but the 49ers' recent scoring pace supports a one-score margin.
06
Qwen 3.8 Max
San Francisco 49ers win
27–17
62%
49ers at Levi's Stadium with home-field edge; H2H shows SF dominating recent matchups despite one upset. Cardinals' defense has been vulnerable to SF's balanced attack.
07
Mistral Medium 3.5
San Francisco 49ers win
28–17
68%
49ers at home with recent H2H dominance and stronger roster depth; Cardinals' offense inconsistent.
08
Kimi K3
San Francisco 49ers win
27–17
62%
49ers have won three of the last five H2H meetings including a 41-22 road win last November; home field at Levi's and Arizona's defensive inconsistency support a moderate home edge.
09
GLM 5.3
San Francisco 49ers win
27–20
58%
49ers won three of the last five H2H including a 41-22 road blowout, and Levi's Stadium home edge helps; Arizona keeps it close, so a moderate one-score margin fits.
10
MiMo V2.6 Pro
San Francisco 49ers win
27–20
60%
49ers home advantage at Levi's Stadium and recent H2H dominance (41-22 win) suggest they can edge this; venue boosts defensive performance.
— Scoreline frequency

How often each scoreline showed up.

5 of 10 models settled on 27–20. That convergence is a strong scoreline signal—many fixtures fan out wider across the panel.

  • 27–20
    5 models
  • 27–21
    2 models
  • 27–17
    2 models
  • 28–17
    1 model

NFL · Week 3

Matchup, injuries and form

The quarterbacks, who is hurt, how both teams have played the last five weeks, and the line next to the AI.

NFL standings & playoff picture →
SpreadTotalWin chance
10 AIs 49ers −7 47 49ers 100%
Quarterback matchup · season
Brock Purdy
Brock Purdy
San Francisco 49ers · QB
249.7 YDS/G 228.6
15 TD 10
4 INT 6
110.1 RATING 82.8
Jacoby Brissett
Jacoby Brissett
Arizona Cardinals · QB

San Francisco 49ers

6-1 · #1 NFC West
Home 4-0 · Road 2-1 · Division 3-0 · Streak L1 · Points 197–139
7 days of rest

Arizona Cardinals

2-5 · #4 NFC West
Home 0-3 · Road 2-2 · Division 1-2 · Streak L1 · Points 142–208
7 days of rest

Injury report

San Francisco 49ers 12 on injured reserve
  • Christian McCaffrey
    Christian McCaffreyRB
    Hamstring
    Questionable
  • Mike Evans
    Mike EvansWR
    Achilles
    Questionable
  • KhaDarel Hodge
    KhaDarel HodgeWR
    Knee
    Questionable
  • GW
    Garret WallowLB
    Hamstring
    Questionable
  • Nick Bosa
    Nick BosaDE
    Knee
    Questionable
  • Luke Gifford
    Luke GiffordLB
    Groin
    Questionable
  • Upton Stout
    Upton StoutCB
    Shoulder - AC Joint
    Questionable
  • MS
    Marques SigleS
    Ankle
    Questionable
Arizona Cardinals 12 on injured reserve
  • Carson Beck
    Carson BeckQB
    Back
    Questionable
  • Jeremiyah Love
    Jeremiyah LoveRB
    Ankle
    Questionable
  • JI
    Jon Gaines II
    Knee
    Questionable
  • Andrew Wingard
    Andrew WingardS
    Knee
    Questionable
  • Max Melton
    Max MeltonCB
    Knee
    Questionable

Last five games, per game

San Francisco 49ers Arizona Cardinals
31 Points scored 16.5
10 Points allowed 22.5
380.5 Total yards 272
246 Passing yards 179
134.5 Rushing yards 93
0.5 Turnovers 0.5
63 Third-down % 35
88 Red-zone TD % 50
2 Sacks 2
31:48Time of possession30:30

Skill players · San Francisco 49ers

  • Christian McCaffrey
    Christian McCaffreyRB
    389 rushing yards (55.6 a game, 4.6 a carry), 8 TD
  • George Kittle
    George KittleTE
    34 catches, 425 receiving yards (60.7 a game), 5 TD
  • Mike Evans
    Mike EvansWR
    27 catches, 420 receiving yards (70 a game), 3 TD

Skill players · Arizona Cardinals

  • Jeremiyah Love
    Jeremiyah LoveRB
    245 rushing yards (49 a game, 3.7 a carry), 1 TD
  • Trey McBride
    Trey McBrideTE
    59 catches, 472 receiving yards (67.4 a game), 4 TD
  • Michael Wilson
    Michael WilsonWR
    37 catches, 375 receiving yards (53.6 a game), 1 TD

Last ten games

San Francisco 49ers WW
Winning and losing margins, oldest to newest
Points scored / allowed
31 / 10
Total over 41.5
1/2
Total over 44.5
1/2
Total over 47.5
1/2
Won by 7+
2/2
Arizona Cardinals LW
Winning and losing margins, oldest to newest
Points scored / allowed
16.5 / 22.5
Total over 41.5
0/2
Total over 44.5
0/2
Total over 47.5
0/2
Won by 7+
1/2

Data and player photos: API-Sports. Market line: bookmaker, for comparison only. Other photos via Wikimedia Commons: Jeremiyah Love by Bobak Ha'Eri (CC BY 3.0), Michael Wilson by Unknown authorUnknown author (Public domain), Upton Stout by Bcschneider53 (CC BY 4.0), Carson Beck by Bobak Ha'Eri (CC BY 3.0), Max Melton by Maize & Blue Nation (CC BY 2.0).

Player props

Prop hit rates: San Francisco 49ers vs Arizona Cardinals

Each line sits at the player's recent average. Bars show every game, green when he went over.

Brock Purdy

Brock Purdy

San Francisco 49ers · QB · last 2 games
Passing yards o246.5 1/2 · 50% Ask AI
205
287
Christian McCaffrey

Christian McCaffrey

San Francisco 49ers · RB · last 2 games
Rushing yards o45.5 1/2 · 50% Ask AI
68
23
George Kittle

George Kittle

San Francisco 49ers · TE · last 2 games
Receiving yards o46.5 1/2 · 50% Ask AI
12
80
Receptions o3.5 1/2 · 50% Ask AI
2
4
Mike Evans

Mike Evans

San Francisco 49ers · WR · last 2 games
Receiving yards o51.5 1/2 · 50% Ask AI
49
54
Receptions o4.5 1/2 · 50% Ask AI
6
3
Jacoby Brissett

Jacoby Brissett

Arizona Cardinals · QB · last 2 games
Passing yards o186.5 1/2 · 50% Ask AI
277
95
Jeremiyah Love

Jeremiyah Love

Arizona Cardinals · RB · last 2 games
Rushing yards o35.5 1/2 · 50% Ask AI
41
29
Trey McBride

Trey McBride

Arizona Cardinals · TE · last 2 games
Receiving yards o68.5 1/2 · 50% Ask AI
95
41
Receptions o8.5 1/2 · 50% Ask AI
9
8
Michael Wilson

Michael Wilson

Arizona Cardinals · WR · last 2 games
Receiving yards o37.5 1/2 · 50% Ask AI
56
18
Receptions o3.5 1/2 · 50% Ask AI
5
2

From box scores of each team's recent games. Lines are our reference points, not sportsbook prices.

San Francisco 49ers vs Arizona Cardinals: quick answers

What is the predicted total for San Francisco 49ers vs Arizona Cardinals?
The AI models' mean predicted score is San Francisco 49ers 27, Arizona Cardinals 20: a projected total of 47 points.
What is the AI spread pick for San Francisco 49ers vs Arizona Cardinals?
The AI consensus has San Francisco 49ers winning by 7 points (27–20).
Who are the quarterbacks in San Francisco 49ers vs Arizona Cardinals?
Brock Purdy (San Francisco 49ers): 1,748 passing yards (249.7 a game), 15 TD, 4 INT, rating 110.1. Jacoby Brissett (Arizona Cardinals): 1,600 passing yards (228.6 a game), 10 TD, 6 INT, rating 82.8.
Who is injured for San Francisco 49ers vs Arizona Cardinals?
San Francisco 49ers have no one listed out or doubtful. Arizona Cardinals have no one listed out or doubtful. Questionable players are on the full report on this page.
— Aggregated insights

What’s moving the panel.

01
Consensus favors San Francisco 49ers

100% of models lean home — the clearest cluster on this fixture before kickoff.

02
Medium confidence

Mean 64% across the panel with real dispersion — compare unanimous calls vs split tickets in the model table.

03
Expected points tilt 27.10 vs 19.30

Derived from predicted scorelines (model means), not live game data — useful for pace vs vote-share sanity checks.

04
Match context

Rest, recent form and home advantage usually decide whether the favourite wins comfortably or the game stays close; check both teams below.

Ask the Council about this match

Pro

10 AI models vote yes or no with this match's last-5 form, head-to-head, live status and the model picks above attached — not from memory. Then keep asking the same council follow-ups.

Ask with match data Ask without data (free)

Confidence trend

Cumulative average confidence in table order.

First model Last model

Match overview

Looking for a today prediction on San Francisco 49ers vs Arizona Cardinals in NFL? TuringStats aggregates multiple AI scorelines into one readable page so you can see who the models favor, the mean predicted score shown in the hero (27 - 20; the frequency chart below lists the most common exact scorelines), and implied splits before kickoff.

This prediction hub is written for readers comparing betting tips-style language with transparent model votes — not a single black-box call. The headline read is San Francisco 49ers win, with vote shares roughly 100% / 0% home and away (rounded).

If you are asking who will win San Francisco 49ers vs Arizona Cardinals, start with the consensus strip and model table, then cross-check form and injuries in Match context further down — that order keeps the strongest signals first.

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